Role of Tyrosine Kinase Receptors in Growth Factor Mediated Signal Transduction, with Specific Reference to MAPK/Rasand p13k-Akt Containing Pathways in Oncogenesis: A Qualitative Database Review

Receptor Tyrosine kinases (RTKs) play a crucial role in the signal transduction pathways at cellular levels. RTK plays vital communication and transmission of signals to adjacent cells regulates different functions cell, such as growth, differentiation, metabolism motility. s triggers growth factor receptors epidermal factor, insulin factor-1 receptor, platelet derived fibro blast receptor vascular endothelial thereby initiating regulating cell proliferation. MAPK/RAS PI3/AKT are major RTK’s function. Dysregulation these often leads many diseases Noonan Syndrome, Logius CFC syndrome types cancer. Point mutation over expression mutations Ras 30% human cancers. Also by too lead several cancers Glioblastoma, Thyroid cancer, Colon cancer Non-small lung PTEN pathway carcinoma relative Thyroid, Skin, Large intestine, eye Bone. Therefore, used targets for therapies. The medical sector uses various small molecule tyrosine kinase inhibitors ATP competitive inhibitors, Allosteric covalent which known Afatinib, Crizotinib, Eroltinib, Icotinib, Lepatinib Lenvatinib treatment management differential carcinomas.